- PII
- S3034630425110138-1
- DOI
- 10.7868/S3034630425110138
- Publication type
- Article
- Status
- Published
- Authors
- Volume/ Edition
- Volume 61 / Issue number 11
- Pages
- 1629-1638
- Abstract
- The synthesis of new sulfur-containing Mannich bases based on 1-octylthiohexan-2-ol, secondary amines (diethylamine, dibutylamine, piperidine, morpholine, hexamethyleneimine) and formaldehyde and study of their antimicrobial properties. A three-component Mannich reaction was used to synthesize the target products. Elemental analysis, IR, H NMR spectroscopy and mass spectrometry were used to determine the structure of the obtained compounds. The disk diffusion method was used to study the antimicrobial activity of the synthesized Mannich bases. It was found that the synthesized compounds have high antimicrobial activity against gram-positive and gram-negative bacteria (, , , ), as well as yeast-like fungi of the genus in comparison with standards (rivanol, furacilin, carbolic acid, chloramine). Based on the obtained results, the synthesized compounds are proposed for use as antimicrobial drugs.
- Keywords
- серосодержащие соединения реакция Манниха основания Манниха аминометокси соединения вторичные амины биологическая активность
- Date of publication
- 11.04.2025
- Year of publication
- 2025
- Number of purchasers
- 0
- Views
- 26
References
- 1. Гулюкина Н.С., Макухин Н.Н., Белецкая И.П. Усп. хим. 2016, 85, 667–683.
- 2. Goulioukina N.S., Makukhin N.N, Beletskaya I.P. Russ. Chem. Rev. 2016, 85, 667–683. https://doi.org/10.1070/RCR4579
- 3. Мамедбейли Э.Г., Исмайылова C.В., Гаджиева Г.Э., Джафарова Н.А., Сулейманова Э.И. ЖОрХ. 2022, 58, 1088–1096.
- 4. Mammadbayli E.H., Ismayilova S.V., Hajieva G.E., Jafarova N.A., Suleymanova E.I. Russ. J. Org. Chem. 2022, 58, 1088–1096.https://doi.org/10.31857/S0514749222100068
- 5. Shi S., Qiu W., Miao P. Nat. Commun. 2021, 12, 1006–1010. https://doi.org/10.1038/s41467-021-21303-3
- 6. Мамедбейли Э.Г., Гаджиева Г.Э., Ибрагимли С.И., Джафарова Н.А. Журнал общей химии. 2018, 88, 1718–1722.
- 7. Mammadbayli E.H., Hajieva G.E., Ibrahinli S.I., Jafarova N.A. Russ. J. Gen. Chem. 2018, 88, 1718–1722. https://doi.org/10.1134/S0044460X18100220
- 8. Мамедбейли Э.Г., Джафаров И.А., Астанова А.Д., Магеррамова Л.М., Джафарова Н.А. Журнал общей химии. 2020, 90, 85–91.
- 9. Mammadbayli E.H., Jafarov I.A., Astanova A.D., Maharramova L.M., Jafarova N.A. Russ. J. Gen. Chem. 2020, 90, 85–91. https://doi.org/10.31857/S0044460X20010102
- 10. Anu K., Saman B.N., Neha Sh. Int. J. Med. Chem. 2014, 14, 1–15. https://doi.org/10.1155/2014/191072
- 11. Мамедбейли Э.Х., Гаджиева Г.А., Джафаров И.А. Реакция аминометилирования в синтезе биологически активных производных норборнена. Баку: Элм, 2022, 376.
- 12. Mammadbayli E.H., Hajieva G.E., Jafarov I.A. Elm, Baku, 2022, 376, ISBN 978-9952-435-66-0.
- 13. Allochio Filho, Joao F., Barbara C., Lemos G. Tetrahedron. 2017, 73, 6977–6989. https://doi.org/10.1016/j.tet.2017.10.063
- 14. Hozien Z., Mahdy A., Markeb A., Hassan L. RSC Advance. 2020, 10, 20184–20194. https://doi.org/10.1039/D0RA02872J
- 15. Wahaibi L., Mohamed A., Tawfik S., Hanan H. Molecules. 2021, 26, 2110–2117. https://doi.org/10.3390/molecules26082110
- 16. Musawi Th., Jawad M. Al-Rafalain J. Med. Sci. 2024, 6, 201–208. https://doi.org/10.54133/ajms.v6i2.835
- 17. Abdula A., Qarah A., Alatawi K., Matokah A. Heliyon. 2024, 10, 28573–28577. https://doi.org/10.1016/j.heliyon.2024.e28573
- 18. Majeed W., Bager Sh., Alsahil S. J. of Med. and Chem. Sciences. 2023, 6, 789–802.
- 19. Essam H., Masaret Gh., Khairou Kh. Chem. Cent. J. 2015, 25, 9–15. https://doi.org/10.1186/s13065-015-0101-8
- 20. Юрьев Ю.К. Практические работы по органической химии. Изд. Московск. Унив., 1961, 420.
