- PII
- S30346304S0514749225020062-1
- DOI
- 10.7868/S3034630425020062
- Publication type
- Article
- Status
- Published
- Authors
- Volume/ Edition
- Volume 61 / Issue number 2
- Pages
- 167-171
- Abstract
- The synthesis of bicyclic allyl acetate 2, a promising precursor of (-)-galileolactone 1, is described. The approach is based on the separation of diastereomeric carboxamides obtained by amidation of racemic gem-dichloro-substituted Grieco lactone with (+)-α-methylbenzylamine. Subsequent steps of transformation of an individual diastereomer include reactions of complete reductive dechlorination, construction of an allyl alcohol fragment in the ring part by stereo- and regiospecific bromohydroxylylation with NBS in aqueous THF, and dehydrobromination.
- Keywords
- бициклические γ-лактоны галиеллалактоны бромгидроксилирование галои-минолактонизация (+)-α-метилбензиламин лактон Грико
- Date of publication
- 13.10.2024
- Year of publication
- 2024
- Number of purchasers
- 0
- Views
- 25
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