Synthesis of Substituted Thienopyrimidinones Based on 2-Amino-4-(1,4-benzodioxan-2-yl) Thiophene-3-carboxylic Acid Ethyl Ester

Vartanyan, S. O.; Avagyan, A. S.; Sargsyan, A. B.; Harutyunyan, S. A.; Gasparyan, H. V.; Aghekyan, A. A.

doi:10.7868/S3034630425040109

PII

S30346304S0514749225040109-1

DOI

10.7868/S3034630425040109

Publication type

Article

Status

Published

Authors

S. O. Vartanyan

Affiliation: The Scienctific Technological Centre of Organic and Pharmaceutical Chemistry NAS RA

A. S. Avagyan

Affiliation: The Scienctific Technological Centre of Organic and Pharmaceutical Chemistry NAS RA

A. B. Sargsyan

Affiliation: The Scienctific Technological Centre of Organic and Pharmaceutical Chemistry NAS RA

S. A. Harutyunyan

Affiliation: The Scienctific Technological Centre of Organic and Pharmaceutical Chemistry NAS RA

H. V. Gasparyan

Affiliation: The Scienctific Technological Centre of Organic and Pharmaceutical Chemistry NAS RA

A. A. Aghekyan

Affiliation: The Scienctific Technological Centre of Organic and Pharmaceutical Chemistry NAS RA

Volume/ Edition

Volume 61 / Issue number 4

Pages

447-452

Abstract

The previously obtained N-arylamides of 2-amino-4-(1,4-benzodioxan-2-yl)thiophene-3-carboxylic acid ethyl ester were cyclized to 2-aryl-substituted 3-aminothienopyrimidin-4-ones by the action of hydrazine hydrate. By condensation of the starting amino ester with chloroacetic acid chloride was obtained chloramide, which was converted by the action of piperidine and morpholine into the corresponding aminomethylamides. The latters were also subjected to cyclization with hydrazine hydrate to 3-aminothienopyrimidin-4-one derivatives with aminomethyl substituents in the second position. The antihypoxic activity of the synthesized compounds was studied.

Keywords

1,4-бензодиоксан хлорамид этиловый эфир 2-амино-4-(1,4-бензодиоксан-2-ил)тиофен-3-карбоновой кислоты тиенопиримидин-4-он циклизация

Date of publication

11.12.2025

Year of publication

2025

Number of purchasers

Views

References

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GOST	Aghekyan A., Avagyan A., Gasparyan H., Harutyunyan S., Sargsyan A., Vartanyan S. Synthesis of Substituted Thienopyrimidinones Based on 2-Amino-4-(1,4-benzodioxan-2-yl) Thiophene-3-carboxylic Acid Ethyl Ester // Russian Journal of Organic Chemistry. – 2025. – V. 61. – Issue number 4 C. 447-452 . URL: https://orgchemras.ru/s30346304s0514749225040109-1/?version_id=119423. DOI: 10.7868/S3034630425040109
MLA	Aghekyan, A. A, Avagyan, A. S, Gasparyan, H. V, Harutyunyan, S. A, Sargsyan, A. B, Vartanyan, S. O "Synthesis of Substituted Thienopyrimidinones Based on 2-Amino-4-(1,4-benzodioxan-2-yl) Thiophene-3-carboxylic Acid Ethyl Ester." Russian Journal of Organic Chemistry. 61.4 (2025).:447-452. DOI: 10.7868/S3034630425040109
APA	Aghekyan A., Avagyan A., Gasparyan H., Harutyunyan S., Sargsyan A., Vartanyan S. (2025). Synthesis of Substituted Thienopyrimidinones Based on 2-Amino-4-(1,4-benzodioxan-2-yl) Thiophene-3-carboxylic Acid Ethyl Ester. Russian Journal of Organic Chemistry. vol. 61, no. 4, pp.447-452 DOI: 10.7868/S3034630425040109

RAS Chemistry & Material ScienceЖурнал органической химии Russian Journal of Organic Chemistry

Synthesis of Substituted Thienopyrimidinones Based on 2-Amino-4-(1,4-benzodioxan-2-yl) Thiophene-3-carboxylic Acid Ethyl Ester

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Индексирование

RAS Chemistry & Material ScienceЖурнал органической химии Russian Journal of Organic Chemistry

Synthesis of Substituted Thienopyrimidinones Based on 2-Amino-4-(1,4-benzodioxan-2-yl) Thiophene-3-carboxylic Acid Ethyl Ester

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