- PII
- S30346304S0514749225050148-1
- DOI
- 10.7868/S3034630425050148
- Publication type
- Article
- Status
- Published
- Authors
- Volume/ Edition
- Volume 61 / Issue number 5
- Pages
- 621-629
- Abstract
- Condensation of 3-benzyl-2-thioxo-2,3-dihydro-1-spiro[benzo[]quinazoline-5,1'-cycloheptane]-4(6)-one with 5,5-dialkyl-2-chloromethylbenzo[]quinazolines were used to synthesize dibenzo[]quinazoline compounds in which spiro[benzo[]quinazoline-5,1'-cycloheptane] in the second position is linked via a -SCH- linker to another benzo[]quinazoline molecule. The specified 2-thioxobenzo[]quinazoline, under similar conditions, upon reaction with methylene iodide, forms 2,2'-[(methylenebis(sulfandilyl))]bis[3-benzyl-3-spiro[benzo[]quinazoline-5,1'-cycloheptane]]-4(6)-one. A transition was made from the starting benzo[]quinazoline to the 2-hydrozimoderivative, which is cleaved in the presence of caustic potash to form 3-benzyl-3-spiro[benzo[]quinazoline-5,1'-cycloheptane]-4(6)-one. Based on the 2-hydrozimo derivative, hydrazone, thiosemicarbazide, and 4-benzyl-4-spiro[benzo[][1,2,4]triazolo[4,3-]quinazoline-6,1'-cycloheptanoenes] have been synthesized. Condensation of 4-benzyl-1-mercapto-4-spiro[benzo[][1,2,4]triazolo[4,3-]quinazoline-6,1'-cycloheptane]-5(7)-one with alkyl halides 1-sulfanyl-substituted triazolobenzo[]quinazoline derivatives of various structures were obtained. The antibacterial properties of the synthesized compounds were studied.
- Keywords
- спиро дибензо[]хиназолин гидразиносоединение гидразон тиосемикарбазид [1,2,4]триазоло[4,3-]хиназолин антибактериальная активность
- Date of publication
- 11.12.2025
- Year of publication
- 2025
- Number of purchasers
- 0
- Views
- 32
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