Synthesis and Antiarrhythmic Activity of New 1,3,4-Oxadiazole Derivatives Containing a 1,4-Benzodioxane Fragment

Avagyan, A. S.

doi:10.31857/S0514749225010053

PII

S0514749225010053-1

DOI

10.31857/S0514749225010053

Publication type

Article

Status

Published

Authors

A. S. Avagyan

Affiliation: Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia

Volume/ Edition

Volume 61 / Issue number 1

Pages

75-81

Abstract

By reacting the previously synthesized 4-(1,4-benzodioxan-6-yl)tetrahydro-2H-pyran-4-carboxylic acid chloride with hydrazine hydrate a symmetrically substituted diacylhydrazine was synthesized, cyclized with phosphorus oxychloride to 2,5-bis-(4-(1,4-benzodioxan-6-yl)tetrahydro-2H-pyran-4-yl)-1,3,4-oxadiazole. For the synthesis of unsymmetrically 2,5-disubstituted 1,3,4-oxadiazoles, the condensation reaction of the above mantione acid chloride with various hydrazides was carried out, and the subsequent cyclization of the resulting diacyl-substituted hydrazines under action of phosphorus oxychloride. The antiarrhythmic properties of the synthesized compounds were studied.

Keywords

1,4-бензодиоксан 1,3,4-оксадиазол оксихлорид фосфора гидразид циклизация антиаритмические свойства

Date of publication

16.09.2025

Year of publication

2025

Number of purchasers

Views

References

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GOST	Avagyan A. Synthesis and Antiarrhythmic Activity of New 1,3,4-Oxadiazole Derivatives Containing a 1,4-Benzodioxane Fragment // Russian Journal of Organic Chemistry. – 2025. – V. 61. – Issue number 1 C. 75-81 . URL: https://orgchemras.ru/s0514749225010053-1/?version_id=107088. DOI: 10.31857/S0514749225010053
MLA	Avagyan, A. S "Synthesis and Antiarrhythmic Activity of New 1,3,4-Oxadiazole Derivatives Containing a 1,4-Benzodioxane Fragment." Russian Journal of Organic Chemistry. 61.1 (2025).:75-81. DOI: 10.31857/S0514749225010053
APA	Avagyan A. (2025). Synthesis and Antiarrhythmic Activity of New 1,3,4-Oxadiazole Derivatives Containing a 1,4-Benzodioxane Fragment. Russian Journal of Organic Chemistry. vol. 61, no. 1, pp.75-81 DOI: 10.31857/S0514749225010053

RAS Chemistry & Material ScienceЖурнал органической химии Russian Journal of Organic Chemistry

Synthesis and Antiarrhythmic Activity of New 1,3,4-Oxadiazole Derivatives Containing a 1,4-Benzodioxane Fragment

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RAS Chemistry & Material ScienceЖурнал органической химии Russian Journal of Organic Chemistry

Synthesis and Antiarrhythmic Activity of New 1,3,4-Oxadiazole Derivatives Containing a 1,4-Benzodioxane Fragment

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