- PII
- S3034630425070073-1
- DOI
- 10.7868/S3034630425070073
- Publication type
- Article
- Status
- Published
- Authors
- Volume/ Edition
- Volume 61 / Issue number 7
- Pages
- 857-869
- Abstract
- The synthesis of selectively 3,4’,6’-tri- and 3,4,4’,6’-tetra--sulfated derivatives of the aminopropyl glycoside of the disaccharide α--GalNAc-(1–2)-α--Fuc (1 and 2), structurally related to highly unusual carbohydrate chain fragments of hexosaminoglycans found in the side chains of fucosylated chondroitin sulfates (FCS) from sea cucumbers and , is described. Spacered disaccharides 1 and 2 were obtained via a common synthetic route involving selectively protected -fucose and phenyl-1-seleno-2-azido-2-deoxygalactose building blocks, the latter synthesized by azidophenylselenylation of triacetylgalactal. Target compounds 1 and 2 will be used as model structures to identify the pharmacophoric elements within these FCS that are responsible for their biological activity.
- Keywords
- природные полисахариды фукоэилированный хондроитинсульфат Array Array гликозилирование азидофенилселенилирование галакталь
- Date of publication
- 01.07.2025
- Year of publication
- 2025
- Number of purchasers
- 0
- Views
- 24
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