- PII
- S3034630425110047-1
- DOI
- 10.7868/S3034630425110047
- Publication type
- Article
- Status
- Published
- Authors
- Volume/ Edition
- Volume 61 / Issue number 11
- Pages
- 1567-1572
- Abstract
- 4-Aryl-2,4-dioxobutanoic acids react with 3-nitro- and 4-nitrobenzohydrazides in a 1:2 ratio to form the corresponding 3-aryl-1-(3-nitrobenzoyl)-5-(2-(3-nitrobenzoyl)hydrazinyl)-4,5-dihydro-1-pyrazole-5-carboxylic acids and 3-aryl-1-(4-nitrobenzoyl)-5-(2-(4-nitrobenzoyl)hydrazinyl)-4,5-dihydro-1-pyrazole-5-carboxylic acids, the structure of which is confirmed by X-ray diffraction analysis. The reaction proceeds under mild conditions with high yields without the use of catalysts and additives, and the isolation process does not require column chromatography. The obtained compounds are promising in terms of the manifestation of various types of biological activity.
- Keywords
- 1-пиразолин-5-карбоновые кислоты 2,4-диоксобутановые кислоты гидразин гетероциклизация антибактериальная активность пиразол пиразолин
- Date of publication
- 19.06.2025
- Year of publication
- 2025
- Number of purchasers
- 0
- Views
- 20
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